Large publishers have quite an advantage: brand recognition, distribution, and money.
I've run into a classic situation where it takes money to make money. I have to sell books to make money, but I have to have money to print the books, in order to sell the books, in order to have money... Argh!
However, I'm a writer, and that means I'm creative and tend to revise things until they turn out the way I want them too. So success is right around the corner... though I don't know quite when we'll get there, or what it will look like, or how may hoops I'll have to jump through... but I can smell it.